Dr. Rosa M. Del Angel was graduated from La Salle University in 1983. She completed her Master in Science with Prof. Carlos Fernández-Tomas in the Department of Genetics and Molecular Biology (1984-1987) at Cinvestav, México. Later she completed her Ph.D. degree with Prof Carlos Fernandez-Tomas at Cinvestav and with Prof. Vincent Racaniello at Columbia University in New York, studying the cellular proteins involved in cap-independent translation of poliovirus. She described for the first time the interaction of cellular proteins such as eIF2 alpha with poliovirus RNA genome. Additionally, she described the role of the nucleotide 472, located in the 5’ untranslated region (5’UTR) of poliovirus in neurovirulence. Upon her return to Mexico, she continued the study of the importance of the 5’UTR of poliovirus in translation and virulence in the Experimental Pathology Department at Cinvestav (1990-1995). Later (1995) she began studies towards the elucidation of the mechanisms involved in dengue virus (DENV) entry and the characterization of cell proteins that interact with DENV genome. Her group described several host molecules involved in viral attachment and entry as well as in binding to viral genome. More recently, her group has characterized the importance of cholesterol in viral entry, replication and morphogenesis and has described how cholesterol levels are modulated during DENV infection. Moreover, her group described that the modulation of cholesterol levels by drugs has an impact in viral replication. In the last year, her group has also obtained important evidence that indicating that during DENV infection epigenetics changes occur as well as modification in the nuclear-cytoplasmic transport favoring viral replication. Dr. del Angel is a member of the editorial board of 2 scientific international journals (Virology and Current Opinion in Virology) and a founding member of the Mexican Network for Virology. Up to date, she has authored 7 book chapters and 69 original research papers.